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PICSI

For many couples experiencing difficulty in conceiving due to fertility-related issues, Assisted Reproductive Techniques (ART) proves to be the harbinger of hope and happiness. Although the advancement in science of human reproduction has increased the chances of success of all fertility treatments exponentially, the experts at Southend Fertility & IVF suggest the best suitable treatment to the couple that helps them conceive at earliest.

The ICSI procedure, an individual sperm is selected and injected into an oocyte. Until now, the only technique available to embryologists to select the sperm has been visual observation. Using PICSI procedure we are able to determine sperm selection in much the same way it happens in human biology.

Sperms are placed in PICSI dish containing samples of hyaluronan hydrogel. Hyaluronan is a naturally occurring biopolymer found in all human cells, including the gel layer surrounding the oocyte.

Mature, biochemically competent sperm bind to the hyaluronan where they can be isolated by the embryologist and used for ICSI.

The principles of this assay are:

  • expression of the protein HspA2, which indicates sperm maturation;
  • cytoplasmic membrane remodeling, which is responsible for the formation of sperm binding sites for the zona pellucida of oocytes and for HA binding sites.

Intracytoplasmic Sperm Injection (ICSI) is one of the fertility treatment techniques that have delivered high rates of fertilization and successful pregnancy of up to 75-80%. ICSI is an Invitro Fertilization (IVF) procedure in which a single sperm cell collected from the semen of the male partner is injected directly into an egg of retrieved from the ovary of the female partner. This approach allows the embryologists to select best quality sperm and egg for fertilization. This procedure can be employed successfully not only in the regular cases of infertility, but also in the cases of previously frozen eggs and/or sperm, donor egg and/or sperm, surrogacy solutions, etc.